Medicine » Tissue Engineering and Regenerative Medicine » "Tissue Engineering for Tissue and Organ Regeneration", book edited by Daniel Eberli, ISBN 978-953-307-688-1, Published: August 17, 2011 under CC BY-NC-SA 3.0 license

Chapter 4

Rapid Prototyping of Engineered Heart Tissues through Miniaturization and Phenotype-Automation

By Tetsuro Wakatsuki
DOI: 10.5772/21199

  1. M. S. Roberts, 2010Improving the Supply of Donor Organs. JAMA: The Journal of the American Medical Association. 304(23): 26432644

  2. S. Yasuda, I. , et al.A. novel, to. method, contraction. study, of. a. characteristics, cardiac. single, using. myocyte, fibers. carbon, Am J Physiol Heart Circ Physiol, 2001H1442H1446

  3. Zimmermann, W.-H., et al., Heart muscle engineering: An update on cardiac muscle replacement therapy.Cardiovascular Research, 2006419429

  4. W. Zimmermann, H. , R. Cesnjevar, Tissue. Cardiac, Implications. Engineering, Pediatric. for, Surgery. Heart, Pediatric Heart Surgery. Pediatric Cardiology, 2009716723

  5. Asnes, C.F., et al., Reconstitution of the Frank-Starling mechanism in engineered heart tissues.Biophys J, 200618001810

  6. T. Wakatsuki, K. W. Lieder, A. Annac, Tissue. Engineered, Innovative. Models, for. Tools, Information. Early-Stage-Dense, Screening. High-Throughput, Drug. for, Discovery, American Biotechnology Laboratory, 2006Nov/Dec).

  7. Nelson, C.M., J.L. Inman, and M.J. Bissell, Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression.Nat. Protocols, 2008674678

  8. Vandenburgh, H., High-Content Drug Screening with Engineered MusculoskeletalTissues. Tissue Engineering Part B: Reviews, 20105564

  9. Marquez, J.P., et al., High-Throughput Measurements of HydrogelTissue Construct Mechanics. Tissue Eng Part C Methods, 2009

  10. Morelock, M.M., et al., Statistics of Assay Validation in High Throughput Cell Imaging of Nuclear Factor κB Nuclear Translocation.ASSAY and Drug Development Technologies, 2005483499

  11. L.H. Hartwell, , et al., From molecular to modular cell biology. Nature.

  12. Cukierman, E., et al., Taking cell-matrix adhesions to the third dimension.Science, 200117081712

  13. Engler, A.J., et al., Extracellular matrix elasticity directs stem cell differentiation. J Musculoskelet Neuronal Interact, 2007335

  14. Pedersen, J.A. and M.A. Swartz, Mechanobiology in the third dimension.Ann Biomed Eng, 200514691490

  15. R. Pankov, et al.A. Rac, regulates. switch, versus. random, persistent. directionally, migration. cell, J Cell Biol, 2005793802

  16. Green, J.A. and K.M. Yamada, Three-dimensional microenvironments modulate fibroblast signaling responses.Adv Drug Deliv Rev, 200712931298

  17. Torsoni, A.S., et al., RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes.American Journal of Physiology- Heart and Circulatory Physiology, 2005H1488H1496

  18. A. Sarasa-Renedo, V. Tunç-Civelek, M. Chiquet, of. Role, A. R. O. C. Rho, actin. K-dependent, in. contractility, induction. the, tenascin. of-C, cyclic. by, strain. tensile, Experimental Cell Research, 200613611370

  19. Ueyama, T., et al., Activated RhoA stimulates c-fos gene expression in myocardial cells.Circ Res, 1997672678

  20. R. Aikawa, et al.family. Rho, G. small, play. proteins, roles. critical, mechanical. in, hypertrophic. stress-induced, in. responses, myocytes. cardiac, Circ Res, 1999458466

  21. Hoshijima, M., et al., The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes.Involvement of Rho kinase. J Biol Chem, 199877257730

  22. Yanazume, T., et al., Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.J Biol Chem, 200286188625

  23. Tomasek, J.J., et al., Myofibroblasts and mechano-regulation of connective tissue remodelling.Nat Rev Mol Cell Biol, 2002349363

  24. Slemp, A.E. and R.E. Kirschner, Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management.Current Opinion in Pediatrics, 2006396402mop.0000236389.41462.ef.

  25. Sawada, Y., et al., Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas.Cell, 200610151026

  26. Small, E.M., et al., Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction.Circ Res, 2010294304

  27. Y. Shi, J. Massagué, of. T. G. Mechanisms, Signaling. F-[beta], Cell. from, to. Membrane, Nucleus. the, Cell, 2003685700

  28. Du, J., et al., TRPM7-Mediated Ca2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation.Circ Res, 20109921003

  29. Sturm, O.E., et al., The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier. Sci. Signal., 2010. 3(153): p. ra90-.

  30. T. Wakatsuki, E. L. Elson, interactions. Reciprocal, cells. between, matrix. extracellular, remodeling. during, tissue. of, constructs, Biophysical Chemistry, 2003593605

  31. Bendig, G., et al., Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart.Genes & Development, 200623612372

  32. KJÆR, M., Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading.Physiological Reviews, 2004649698

  33. Maier, S., et al., Tenascin-C induction by cyclic strain requires integrin-linked kinase.Biochimica et Biophysica Acta (BBA)- Molecular Cell Research, 200811501162

  34. Russo, R., et al., Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma.Clin Rheumatol, 200711361141

  35. Pacher, P., et al., Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats.Nat. Protocols, 200814221434

  36. T. Eschenhagen, W. H. Zimmermann, myocardial. Engineering, Circ. tissue, Res, 200512201231

  37. Kolodney, M.S. and E.L. Elson, Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts.Journal of Biological Chemistry, 19932385023855

  38. T. Wakatsuki, et al.of. Effects, D. cytochalasin, B. latrunculin, mechanical. on, of. properties, cells, J Cell Sci, 2001Pt 5): 10251036

  39. Wakatsuki, T., J.A. Fee, and E.L. Elson, Phenotypic screening for pharmaceuticals using tissue constructs.Curr Pharm Biotechnol, 2004181189

  40. Zutter, M.M., et al., Collagen receptor control of epithelial morphogenesis and cell cycle progression.Am J Pathol, 1999927940

  41. Eschenhagen, T., et al., Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system.Faseb J, 1997683694

  42. Flanagan, N., Tissue Models Boost Drug Discovery Efforts; Eliminating Toxic and Ineffective Compounds at an Early Stage.Genetic Engineering News, 20051

  43. Takahashi, K., et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors.Cell, 2007861872

  44. Yu, J., et al., Human induced pluripotent stem cells free of vector and transgene sequences.Science, 2009797801

  45. Stevens, K.R., et al., Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue.Proceedings of the National Academy of Sciences, 20091656816573

  46. Yang, P.T., et al., Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.Dev Cell, 2008140147

  47. Laflamme, M.A., et al., Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts.Nat Biotechnol, 200710151024

  48. Caspi, O., et al., Tissue engineering of vascularized cardiac muscle from human embryonic stem cells.Circ Res, 2007263272