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Medicine » Hematology » "Blood Cell - An Overview of Studies in Hematology", book edited by Terry E. Moschandreou, ISBN 978-953-51-0753-8, Published: September 21, 2012 under CC BY 3.0 license. © The Author(s).

Chapter 7

Proliferation and Differentiation of Hematopoietic Cells and Preservation of Immune Functions

By Osamu Hayashi
DOI: 10.5772/48322

  1. Y. Akao, T. Ebihara, H. Masuda, Y. Saeki, T. Akazawa, K. Hazeki, O. Hazeki, M. Matsumoto, T. Seya, 2009 "Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice", Cancer Sci, 100 14941501 .

  2. T. Amo, N. Kawanishi, M. Uchida, H. Fujita, E. Oyanagi, T. Utsumi, T. Ogino, K. Inoue, T. Shuin, K. Utsumi, J. Sasaki, 2009 "Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937", Cell Biochem Funct, 27 503515 .

  3. A. D. Bachstetter, J. Jernberg, A. Schlunk, J. L. Vila, C. Hudson, Shytle. R. D. Cole, J. Tan, P. R. Sanberg, C. D. Sanberg, C. Borlongan, Y. Kaneko, N. Tajiri, C. Gemma, P. C. Bickford, 2010 "Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation", PLoS One, 5, e10496.

  4. P. Balachandran, N. D. Pugh, G. , Pasco, 2006 "Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice", Int Immunopharmacol, 6 18081814 .

  5. A. Belay, 2002 "The potential application of Spirulina (Arthorspira) as a nutritional and therapeutic supplement in health management", J Am Nutraceutical Association, 5 2748 .

  6. A. Belay, Y. Ota, K. Miyakawa, H. Shimamatsu, 1993 "Current knowledge on potential health benefits of Spirulina", J Appl Phycol, 5 235241 .

  7. B. Beutler, 2000 "TLR4: central component of the sole mammalian LPS sensor", Current Opinion in Immunology, 12 2026 .

  8. G. Chamorro-Cevallos, 1980 "Toxicological research on the alga Spirulina", Report: United Nations International Development Organization (UNIDO) UF/MEX/78/048, Vienna.

  9. J. W. Chiao, W. F. Freitag, J. C. Steinmetz, M. Andreeff, 1981 "Changes of cellular markers during differentiation of HL-60 promyelocytes to macrophages as induced by T lymphocyte conditioned medium", Leukemia Research, 5 477489 .

  10. O. Ciferri, 1983 "Spirulina, the edible microorganisms", Microbiol Res, 47 551578 .

  11. S. Collins, 2002 "The role of retinoids and retinoic acid receptors in normal hematopoiesis", Leukemia, 16 18961905 .

  12. Cruse, JM, and Lewis, RE 1995 Illustrated Dictionary of Immunology. Florida: CRC Press, Inc.

  13. S. Cunningham-Rundles, 2004 "The effect of aging on mucosal host defense", J Nutr Health Aging, 8 2025 .

  14. M. De la Fuente, 2002 "Effects of antioxidants on immune system ageing", European Journal of Clinical Nutrition, 56 5558 .

  15. K. Ebnet, A. Suzuki, S. Ohno, D. Vestweber, 2004 "Junctional adhesion molecules (JAMs): more molecules with dual functions?", J Cell Sci, 117 1929 .

  16. Wv. Ewijk, A. Hayday, M. Merkenschlager, E. Robey, Bevan, R. Zamoyska, 1999 "7. The thymus and the developement of T lymphocytes", CA Janeway, P Travers, M Walport, & JD Capra (Ed.), In Immunobiology- The immune system in health and disease 4th edition (227260 ). New York: Grand Publishing.

  17. J. A. Fontana, D. A. Colbert, A. B. Deisseroth, 1981 "Identification of a population of bipotent stem cells in the HL60 human promyelocytic leukemia cell line", Proc Natl Acad Sci USA, 78 38633866 .

  18. L. Geitler, 1932 "Rabenhorst’s Kryptogamenflora von Deutschland, Ostereiich nd de Scheweiz". Leipzig: Akad Verlag, pp.

  19. Gershwin, A. Belay, 2008 "Spirulina in Human and Health". Boca Raton, FL: CRC Press Taylor & Francis Group, 312 pp.

  20. R. Grzanna, A. Polotsky, P. V. Phan, N. Pugh, D. Pasco, C. G. Frondoza, 2006 "Immolina, a high-molecular-weight polysaccharide fraction of Spirulina, enhances chemokine expression in human monocytic THP-1 cells", J Altern Complement Med, 12 429435 .

  21. R. Hass, H. Bartels, N. Topley, M. Hadam, L. Köhler, M. Goppelt-Strübe, K. Resch, 1989 "TPA-induced differentiation and adhesion of U937 cells: changes in ultrastructure, cytoskeletal organization and expression of cell surface antigens", Eur J Cell Biol, 48 282293 .

  22. O. Hayashi, T. Hirahashi, T. Katoh, H. Miyajjima, T. Hirano, Y. Okuwaki, 1998 "Class specific influence of dietary Spirulina platensis on antibody production in mice", J Nutr Sci Vitaminol, 44 841851 .

  23. O. Hayashi, K. Ishii, Y. Kato, 2008 "Spirulina and Antibody Production", M Gershwin, & A Belay (Ed.), In Spirulina in Human Nutrition and Health (205226 ). Boca Raton, FL: CRC Press Taylor & Francis Group.

  24. O. Hayashi, T. Katoh, Y. Okuwaki, 1994 "Enhancement of antibody production in mice by dietary Spirulina platensis", J. Nutr. Sci. Vitaminol., 40 431441 .

  25. O. Hayashi, S. Ono, K. Ishii, Y. Shi, T. Hirahashi, T. Katoh, 2006 "Enhancement of proliferation and differentiation in bone marrow hematopoietic cells by Spirulina (Arthrospira) platensis in mice", Journal of Applied Phycology, 18 4756 .

  26. T. Hayashi, K. Hayashi, M. Maeda, I. Kojima, 1996 "Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis", J Nat Prod, 59 8387 .

  27. A. Hayday, E. Theodoridis, E. Ramsburg, J. Shires, 2001 "Intraepithelial lymphocytes: exploring the Third Way in immunology", Nat. Immun., 2, 997.

  28. T. Hirahashi, M. Matsumoto, K. Hazeki, Y. Saeki, M. Ui, T. Seya, 2002 "Activation of the human innate immune system by Spirulina: augmentaion of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis.", International Immunopharmacology, 2 423734 .

  29. Ihle, JN 1992 "Interleukin-3 and hematopoiesis", Chem. Immunol., 51 65106 .

  30. K. Ishii, T. Katoh, Y. Okuwaki, O. Hayashi, 1999 "Influence of dietary Spirulina platensis on IgA level in human saliva", Joshi Eiyo Daigaku Kiyou, 30, 27-33 (in Japanese).

  31. K. Ishii, Y. Shi, T. Katoh, O. Hayashi, 2009 "Effect of Phycocyanin, one of the extracts of Spirulina, on differentiation of U937 and HL-60 human myeliod leukemia cell lines", J Phys Fit Nutr Immunol, 19 222232 .

  32. S. Kaminogawa, M. Nanno, 2004 "Modulation of Immune Functions by Foods", Evid Based Complement Alternat Med, 1 241250 .

  33. J. Kaszuba-Zwoinska, K. Wojcik, M. Bereta, A. Ziomber, P. Pierzchalski, E. Rokita, J. Marcinkiewicz, W. Zaraska, P. Thor, 2010 "Pulsating electromagnetic field stimulation prevents cell death of puromycin treated U937 cell line", J Physiol Pharmacol, 61 201205 .

  34. J. Kim, I. Takahashi, Y. Kai, H. Kiyono, 2001 "Influence of enterotoxin on mucosal intranet: selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin", Eur J Immunol, 31 29602969 .

  35. T. Koga, J. R. Mc Ghee, H. Kato, R. Kato, H. Kiyono, K. Fujihashi, 2000 "Evidence for early aging in the mucosal immune system", Journal of Immunology, 165 5352 -5359.

  36. H. Komano, Y. Fujiura, M. Kawaguchi, S. Matsumoto, Y. Hashimoto, S. Obana, P. Mombaerts, S. Tonegawa, H. Yamamoto, S. Itohara, et al. 1995 "Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells", Proceedings of the National Academy of Sciences of the United States of America, 92 61476151 .

  37. Komuro, T, Sano, K, Asano, Y, and Tada, T (1990). "Analysis of aged-related degeneracy of T-cell repertoir: Localized functional failure in CD8+ T cells", Scandinavian journal of immunology, 32, 545-553.

  38. D. Krause, A. M. Mastro, G. Handte, H. Smiciklas-Wright, M. P. Miles, D. Ahluwalia, 1999 "Immune function did not decline with aging in aooarently healthy, well-nourished women", Mech Ageing Dev, 112 4357 .

  39. L. Lefrancois, 1991 "Phenotypic complexity of intraepithelial lymphocytes of small intestine", Journal of Immunology, 147, 1746.

  40. B. Li, M. H. Gao, X. C. Zhang, X. M. Chu, 2006 "Molecular immune mechanism of C-phycocyanin from Spirulina platensis induces apoptosis in HeLa cells in vitro", Biotechnol Appl Biochem, 43 155164 .

  41. Loseva, LP, and Dardynskaya, IV 1993 Spirulina natural sorbent of radionucleides. In the 6th International Congress of Applied Algology. Czech Republic.

  42. Y. C. Lu, W. C. Yeh, P. S. Ohashi, 2008 "LPS/TLR4 signal transduction pathway", Cytokine, 42 145151 .

  43. M. Lubbert, F. Herrmann, H. P. Koeffler, 1991 "Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells", Blood, 77 909924 .

  44. P. Lydyard, C. Grossi, 1998 "3. Lymphoid system", I Roitt, J Brostoff, & D Male (Ed.), In Immunology 5th edition (3141 ). London: Mosby International Ltd.

  45. Coll. R. Mac, 2004 "Allophycocyanin and energy transfer", Biochim Biophys Acta, 1657, 7381 .

  46. T. K. Mao, J. Van De Water, Gershwin, 2000 "Effect of Spirulina on the secretion of cytokines from peripheral blood mononuclear cells", Journal of Medicinal Food, 3 (3), 135-140.

  47. J. Miquel, 2001 "Nutrition and ageing", Public Health Nutrition, 4 (6A), 13851388 .

  48. T. Mishima, J. Murata, M. Toyoshima, H. Fujii, M. Nakajima, T. Hayashi, T. Kato, I. Saiki, 1998 "Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis", Clin Exp Metastasis, 16 541550 .

  49. B. Nelissen, A. Wilmotte, R. De Baere, F. Haes, Y. Van De Peer, J. Neefs, 1992 "Phylogenetic study of cyanobacteria on the basis of 16S ribosomal RNA sequences", Belg J Bot, 125 210213 .

  50. C. Nemoto-Kawamura, T. Hirahashi, T. Nagai, H. Yamada, T. Katoh, O. Hayashi, 2004 "Phycocyanin enhances secretory IgA antibody responses and suppresses allergic IgE antibody response in mice immunized with antigen-entrapped biodegradable microparticles", J Nutr Sci Vitaminol, 50 129136 .

  51. H. Obermeier, N. Hrboticky, A. Sellmayer, 1995 "Differential effects of polyunsaturated fatty acids on cell growth and differentiation of premonocytic U937 cells", Biochim Biophys Acta, 1266 179185 .

  52. A. Otte, K. Mandel, G. Reinstrom, R. Hass, 2011 "Abolished adherence alters signaling pathways in phorbol ester-induced human U937 cells", Cell Commun Signal, 9, 20.

  53. A. K. Padyana, V. B. Bhat, K. M. Madyastha, K. Rajashankar, S. Ramakumar, 2001 "Crystal Structure of a Light-Harvesting Protein C-Phycocyanin from Spirulina platensis", Biochemical and Biophysical Research Communications, 282 893898 .

  54. E. J. Park, I. Takahashi, J. Ikeda, K. Kawahara, T. Okamoto, M. N. Kweon, S. Fukuyama, V. Groh, T. Spies, Y. Obata, J. Miyazaki, H. Kiyono, 2003 "Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium", Journal of Immunology, 171 41314139 .

  55. G. Pentón-Rol, G. Martínez-Sánchez, M. Cervantes-Llanos, N. Lagumersindez-Denis, Acosta. Felino-Medina, E. Falcón-Cama, V. Alonso-Ramírez, R. Valenzuela-Silva, C. Rodríguez-Jiménez, E. Llópiz-Arzuaga, A. Marín-Prida, J. López-Saura, P. A. Guillén-Nieto, G. E. , E. Pentón-Arias, 2011 "C-Phycocyanin ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells", International Immunopharmacology 11 2938 .

  56. N. Pugh, S. A. Ross, H. N. El Sohly, El Sohly, Pasco, 2001 "Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomenon flosaquae and Chlorella pyrenoidosa", Planta Med, 67 737742 .

  57. B. Rabadiya, P. Patel, 2010 "Spirulina: Potential clinical therapeutic application", Journal of Pharmacy Research, 3 17261732 .

  58. R. D. Rao, P. M. Anderson, Wettstein. P. J. Arndt, S. N. Markovic, 2003 "Aerosolized granulocyte macrophage colony-stimulating factor (GM-CSF) therapy in metastatic cancer", Am J Clin Oncol, 26 493498 .

  59. C. M. Reddy, V. B. Bhat, G. Kiranmai, M. N. Reddy, P. Reddanna, K. M. Madyastha, 2000 "Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis", Biochem Biophys Res Commun, 277 599603 .

  60. D. Remirez, N. Ledon, R. Gonzalez, 2002 "Role of histamine in inhibitory effects of phycocyanin in experimental models of allergic inflammatory response", Mediators of Inflammation, 11 8185 .

  61. B. Rocha, P. Vassalli, D. Guy-Grand, 1994 "Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice", J Exp Med, 180 681686 .

  62. C. Romay, J. Armesto, D. Remirez, R. Gonzalez, N. Ledon, I. Garcia, 1998 "Antioxidant and anti-inflammatory properties of c-phycocyanin from blue-green algae", Inflammation Research, 47 3641 .

  63. T. Sacha, M. Zawada, J. Hartwich, Z. Lach, A. Polus, M. Szostek, Owska. E. Zdzi, M. Libura, M. Bodzioch, A. Dembińska-Kieć, A. Skotnicki, R. Góralczyk, K. Wertz, G. Riss, C. Moele, T. Langmann, G. Schmitz, 2005 "The effect of beta-carotene and its derivatives on cytotoxicity, differentiation, proliferative potential and apoptosis on the three human acute leukemia cell lines: U-937, HL-60 and TF-1", Biochim Biophys Acta, 1740 206214 .

  64. D. L. Schmucker, R. L. Owen, R. Outenreath, K. Thoreux, 2003 "Basis for the age-related decline in intestinal mucosal immunity", Clin Dev Immunol, 10 167172 .

  65. E. Schneider, M. Dy, 1999 "Cytokines and haematopoiesis", J Theze (Ed.), In The Cytokine Network and Immune Functions (146161 ). New York: Oxford University Press.

  66. C. Selmi, P. S. Leung, L. Fischer, B. German, C. Y. Yang, T. P. Kenny, G. R. Cysewski, Gershwin, 2011 "The effects of Spirulina on anemia and immune function in senior citizens", Cell Mol Immunol, 8 248254 .

  67. K. Shinohara, Y. Okura, T. Koyano, H. Murakami, H. Omura, 1988 "Algal phycocyanins promote growth of human cells in culture", In Vitro Cellular and Developmental Biology, 2 10571060 .

  68. R. Solana, G. Pawelec, R. Tarazona, 2006 "Aging and innate immunity", Immunity, 24 491494 .

  69. Takimoto, H, Nakamura, T, Takeuchi, M, Sumi, Y, Tanaka, T, Nomoto, K, and Yoshikai, Y (1992). "Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats", Eur J Immunol, 22, 159-164.

  70. K. Tamagawa, S. Fukushima, M. Kobori, H. Shinmoto, T. Tsushida, 1998 "Proanthocyanidins from barley bran potentiate retinoic acid-induced granulocytic and sodium butyrate-induced monocytic differentiation of HL60 cells", Bioscience, Biotechnology, and Biochemistry, 62 14831487 .

  71. Tanaka, H, Abe, E, Miyaura, C, Shiina, Y, and Suda, T (1983). "1 alpha, 25-dihydroxyvitamin D3 induces differentiation of human promyelocytic leukemia cells (HL-60) into monocyte-macrophages, but not into granulocytes", Biochem Biophys Res Commun, 117, 86-92.

  72. S. J. Tudhope, T. K. Finney-Hayward, A. G. Nicholson, R. J. Mayer, Barnes. P. J. Barnette, L. E. Donnelly, 2008 "Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage", The Journal of Pharmacology and Experimental Therapeutics, 324 306312 .

  73. B. B. Vadiraja, N. W. Gaikwad, K. M. Madyastha, 1998 "Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats", Biochem Biophys Res Commun, 249 428431 .

  74. S. Verma, R. Samarth, M. Panwar, 2006 "Evaluation of Radioprotective Effects of Spirulina in Swiss Albino Mice", Asian J Exp Sci, 20 121126 .

  75. J. Vila, C. Gemma, A. Bachstetter, Y. Wang, I. Stromberg, P. C. Bickford, 2008 "Spirulina, aging, and neurobiology", ME Gershwin, & A Belay (Ed.), In Spirulina in Human Nutrition and Health (271291 ). Boca Raton, FL: CRC Press Taylor & Francis Group.

  76. Wu, L-c, and Annie Ho, J-a 2008 "Antioxidative and hepatoprotective effects of Spirulina", ME Gershwin, & A Belay (Ed.), In Spiruilina in Human Nutrition and Health (119151 ). Boca Raton, FL: CRC Oress Taylor & Francis Group.

  77. Zhang, C-W 1994 "Effect of polysaccharide and phycocyanin from Spirulina on peripheral blood and hematopoietic system of bone marrow in mice", Proceeding of 2nd Asia Pacific Conference on Algal Biotechnology, China, 58.

  78. H. Zhang-Q, A. Lin-P, Y. Sun, Y. Deng-M, 2001 "Chemo and radio-protective effects of polysaccharide of Spirulina platensis in hemopoeitic system of mice and dogs", Acta Pharmacol Sin 22 11211124 .