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Proteomics - Human Diseases and Protein Functions
Edited by Tsz-Kwong Man and Ricardo J. Flores, ISBN 978-953-307-832-8, Hard cover, 438 pages, Publisher: InTech, Published: February 10, 2012 under CC BY 3.0 license, in subject Immunology and Microbiology
DOI: 10.5772/1288
Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.
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Book contents
- Chapter 1Overview of Current Proteomic Approaches for Discovery of Vascular Biomarkers of Atherosclerosis
- Chapter 2From Biomarker Discovery to Clinical Evaluation for Early Diagnosis of Lung Surgery-Induced Injury
- Chapter 3Urinary Exosomes for Protein Biomarker Research
- Chapter 4Circadian Proteomics and Its Unique Advantage for Discovery of Biomarkers of Heart Disease
- Chapter 5Exploring the Role of Biomarkers for the Diagnosis and Management of Traumatic Brain Injury Patients
- Chapter 6Comparative Proteomics: An Approach to Elucidating the Function of a Novel Gene Called BRE
- Chapter 7Proteomic Approaches to Unraveling the RB/E2F Regulatory Pathway
- Chapter 8F0F1 ATP Synthase: A Fascinating Challenge for Proteomics
- Chapter 9Proteomic Analysis of Wnt-Dependent Dishevelled-Based Supermolecular Complexes
- Chapter 10Identification of the Novel Plasminogen Receptor, Plg-RKT
- Chapter 11Posttranslational Modifications of Myosin Light Chains Determine the Protein Fate
- Chapter 12Proteomic Study of Esophageal Squamous Cell Carcinoma
- Chapter 13Multidimensional Proteomics for the Identification of Endothelial Post Mortem Signals of Importance in Vascular Remodeling
- Chapter 14The Microtubule-Dissociating Tau in Neurological Disorders
- Chapter 15Identification of Factors Involved in Neurogenesis Recovery After Irradiation of the Adult Mouse Subventricular Zone: A Preliminary Study
- Chapter 16Analysis of Organelle Dynamics by Quantitative Mass Spectrometry Based Proteomics
- Chapter 17Mitochondrial Proteomics: From Structure to Function
- Chapter 18Proteomic Analysis of Plasma Membrane Proteins in an In Vitro Blood-Brain Barrier Model
- Chapter 19Quantitative Proteomics for Investigation of Secreted Factors: Focus on Muscle Secretome
