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Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring
Edited by Raymond Chuen-Chung Chang, ISBN 978-953-307-485-6, Hard cover, 558 pages, Publisher: InTech, Published: December 09, 2011 under CC BY 3.0 license, in subject Mental and Behavioural Disorders and Diseases of the Nervous System
DOI: 10.5772/1252
Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. This book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. Although the primary etiology for different neurodegenerative diseases is different, there is a high level of similarity in the disease processes. The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glial cells modulate or promote neurodegeneration. In the next section an evaluation is given of how hormonal and metabolic control modulate disease progression, which is followed by a section exploring some preventive methods using natural products and new pharmacological targets. We also explore how medical devices facilitate patient monitoring. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
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Book contents
- Chapter 1What is the Link Between Protein Aggregation and Interneuronal Lesion Propagation in Neurodegenerative Disease?
- Chapter 2Roles of Microtubules in Maintenance of Nerve Cell Networks
- Chapter 3Oxidative Stress and Neurodegenerative Disease
- Chapter 4Free Radicals in Neurodegenerative Diseases: Modulation by Palladium α-Lipoic Acid Complex
- Chapter 5Docosahexaenoic Acid (DHA), in the Prevention and Treatment of Neurodegenerative Diseases
- Chapter 6Effect of Zinc and DHA on Expression Levels and Post-Translational Modifications of Histones H3 and H4 in Human Neuronal Cells
- Chapter 7Free Radicals, Neuronal Death and Neuroprotection
- Chapter 8Neuropathological Disorders and Calcium Independent Forms of Phospholipase A2 Activities in the Brain
- Chapter 9ASK1 and Its Role in Neurodegenerative Diseases
- Chapter 10Role of Connexin Hemichannels in Neurodegeneration
- Chapter 11Role of Astrocytes in Neurodegenerative Diseases
- Chapter 12Alteration of Neuron-Glia Interactions in Neurodegeneration: Molecular Biomarkers and Therapeutic Strategy
- Chapter 13Microglia, Calcification and Neurodegenerative Diseases
- Chapter 14Analysis of the Impact of CD200 on Neurodegenerative Diseases
- Chapter 15Hormonal Signaling Systems of the Brain in Diabetes Mellitus
- Chapter 16Can VEGF-B Be Used to Treat Neurodegenerative Diseases?
- Chapter 17Power of a Metabonomic Approach to Investigate an Unknown Nervous Disease
- Chapter 18Extract of Achillea fragrantissima Downregulates ROS Production and Protects Astrocytes from Oxidative-Stress-Induced Cell Death
- Chapter 19Quantification of Volumetric Changes of Brain in Neurodegenerative Diseases Using Magnetic Resonance Imaging and Stereology
- Chapter 20Acid-Sensing Ion Channels in Neurodegenerative Diseases: Potential Therapeutic Target
- Chapter 21Genome Profiling and Potential Biomarkers in Neurodegenerative Disorders
- Chapter 22Immunization with Neural-Derived Peptides as a Potential Therapy in Neurodegenerative Diseases
- Chapter 23Neurodegenerative Disease Monitoring Using a Portable Wireless Sensor Device
