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Metabolomics
Edited by Ute Roessner, ISBN 978-953-51-0046-1, Hard cover, 364 pages, Publisher: InTech, Published: February 10, 2012 under CC BY 3.0 license, in subject Biochemistry, Genetics and Molecular Biology
DOI: 10.5772/1237
Metabolomics is a rapidly emerging field in life sciences, which aims to identify and quantify metabolites in a biological system. Analytical chemistry is combined with sophisticated informatics and statistics tools to determine and understand metabolic changes upon genetic or environmental perturbations. Together with other 'omics analyses, such as genomics and proteomics, metabolomics plays an important role in functional genomics and systems biology studies in any biological science. This book will provide the reader with summaries of the state-of-the-art of technologies and methodologies, especially in the data analysis and interpretation approaches, as well as give insights into exciting applications of metabolomics in human health studies, safety assessments, and plant and microbial research.
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Book contents
- Chapter 1Metabolomics and Mammalian Cell Culture
- Chapter 2Quantitative Metabolomics and Its Application in Metabolic Engineering of Microbial Cell Factories Exemplified by the Baker’s Yeast
- Chapter 3Online Metabolomics Databases and Pipelines
- Chapter 4Generic Software Frameworks for GC-MS Based Metabolomics
- Chapter 5Computational Methods to Interpret and Integrate Metabolomic Data
- Chapter 6Metabotype Concept: Flexibility, Usefulness and Meaning in Different Biological Populations
- Chapter 7Software Techniques for Enabling High-Throughput Analysis of Metabolomic Datasets
- Chapter 8Metabolic Pathways as Targets for Drug Screening
- Chapter 9New Opportunities in Metabolomics and Biochemical Phenotyping for Plant Systems Biology
- Chapter 10Metabolomics of Endophytic Fungi Producing Associated Plant Secondary Metabolites: Progress, Challenges and Opportunities
- Chapter 11Metabolomics in the Analysis of Inflammatory Diseases
- Chapter 12Clinical Implementation of Metabolomics
- Chapter 13Improvement in the Number of Analytic Features Detected by Non-Targeted Metabolomic Analysis: Influence of the Chromatographic System and the Ionization Technique
- Chapter 14Challenges for Metabolomics as a Tool in Safety Assessments
- Chapter 15Metabolomics Approach for Hazard Identification in Human Health Assessment of Environmental Chemicals
