Medicine » Mental and Behavioural Disorders and Diseases of the Nervous System

Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

Edited by Suzanne De La Monte, ISBN 978-953-307-690-4, 686 pages, Publisher: InTech, Chapters published September 12, 2011 under CC BY-NC-SA 3.0 license
DOI: 10.5772/951

Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

Dr. Suzanne De La Monte

Brown University, United States of America

Dr. Suzanne M. de la Monte, M.D., M.P.H. is Professor of Neuropathology, Neurology, and Neurosurgery at the Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI. She received her undergraduate degree from Cornell University, Ithaca, N.Y., M.D. from the Weill College of Medicine at Cornell University, and masters in public health (M.P.H.) from the Blumberg School of Public Health at Johns Hopkins University, Baltimore, MD. Dr. de la Monte completed her residency in Anatomical Pathology and fellowship in Pediatric Pathology at The Johns Hopkins Hospital, and a fellowship in Neuropathology at the Massachusetts General Hospital. She received postdoctoral research training at the Massachusetts General Hospital. Currently, Dr. de la Monte directs research on the role of insulin resistance as a mediator of neurodegeneration in relation to Alzheimer’s disease, alcoholism, obesity, diabetes, and development. Her research led to the provocative concept that Alzheimer’s is “Type 3 Diabetes”.

Experience

Edited Books

  • The Clinical Spectrum of Alzheimer's Disease -The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies

    The Clinical Spectrum of Alzheimer's Disease: The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies is highly informative and current. Acknowledged experts in the field critically review both standard and under-appreciated clinical, behavioral, epidemiological, genetic, and neuroimaging attributes of Alzheimer's disease. The collection covers diverse topics of interest to clinicians and researchers alike. Experienced professionals and newcomers to the field will benefit from the read. The strengths and weaknesses of current clinical, non-invasive, neuro-imaging, and biomarker diagnostic approaches are explained. The perspectives give fresh insights into the process of neurodegeneration. Readers will be enlightened by the evidence that the neural circuits damaged by neurodegeneration are much broader than conventionally taught, suggesting that Alzheimer's could be detected at earlier stages of disease by utilizing multi-pronged diagnostic approaches. This book inspires renewed hope that more effective treatments could be developed based upon the expanding list of potential therapeutic targets.

  • Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

    Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

Publications