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Biochemistry, Genetics and Molecular Biology
DNA Replication-Current Advances
Edited by Herve Seligmann, ISBN 978-953-307-593-8, Hard cover, 694 pages, Publisher: InTech, Chapters published August 01, 2011 under CC BY-NC-SA 3.0 license
DOI: 10.5772/791
The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication. As several contributions in this book show, the study of DNA will continue for a while to be a leading front of scientific activities.
- Chapter 1
DNA Structure: Alphabet Soup for the Cellular Soul - Chapter 2
Replication Demands an Amendment of the Double Helix - Chapter 3
Phosphorothioation: An Unusual Post-Replicative Modification on the DNA Backbone - Chapter 4
Mitosis and DNA Replication and Life Origination Hydrate Hypotheses: Common Physical and Chemical Grounds - Chapter 5
Strand-specific Composition Bias in Bacterial Genomes - Chapter 6
Mutation Patterns Due to Converging Mitochondrial Replication and Transcription Increase Lifespan, and Cause Growth Rate-Longevity Tradeoffs - Chapter 7
Mitochondrial DNA Replication in Health and Disease - Chapter 8
Damage and Replication Stress Responses - Chapter 9
Relationship between Fork Progression and Initiation of Chromosome Replication in E. coli - Chapter 10
Replication Origin Selection and Pre-Replication Complex Assembly - Chapter 11
The Coordination between DNA Replication Initiation and Other Cell Cycle Events - Chapter 12
The Organisation of Replisomes - Chapter 13
Eukaryotic Replication Barriers: How, Why and Where Forks Stall - Chapter 14
Control of Telomeric DNA Replication: Genetics, Molecular Biology, and Physiology - Chapter 15
Telomere Maintenance in Organisms without Telomerase - Chapter 16
Eukaryote DNA Replication and Recombination: an Intimate Association - Chapter 17
Cell Cycle Regulation of DNA Replication in S. cerevisiae - Chapter 18
Free Histones and the Cell Cycle - Chapter 19
Involvement of Linker Histones in the Regulation of Replication Timing - Chapter 20
Replication Timing: Evolution, Nuclear Organization and Relevance for Human Disease - Chapter 21
The Silencing Face of DNA Replication: Gene Repression Mediated by DNA Replication Factors - Chapter 22
Faithful DNA Replication Requires Regulation of CDK Activity by Checkpoint Kinases - Chapter 23
Regulation of the G1/S Transition in Adult Liver: Expression and Activation of the Cyclin Dependent Kinase Cdk1 in Differentiated Hepatocytes is Controlled by Extracellular Signals and is Crucial for Commitment to DNA Replication - Chapter 24
Binding of Human MCM-BP with MCM2-7 Proteins - Chapter 25
DNA Replication in Animal Systems Lacking Thioredoxin Reductase I - Chapter 26
Prevalence of Reactivation of Hepatitis B Virus DNA Replication in Rheumatoid Arthritis Patients - Chapter 27
Oncogenic Aspects of HPV Infections of the Female Genital Tract - Chapter 28
The Role of E2 Proteins in Papillomavirus DNA Replication - Chapter 29
Topoisomerase I and II Expression in Recurrent Colorectal Cancer Cells: A Dubious Matter - Chapter 30
Bacterial Genetics of Large Mammalian DNA Viruses: Bacterial Artificial Chromosomes as a Prerequisite for Efficiently Studying Viral DNA Replication and Functions

