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DNA Replication-Current Advances
Edited by Herve Seligmann, ISBN 978-953-307-593-8, Hard cover, 694 pages, Publisher: InTech, Published: August 01, 2011 under CC BY-NC-SA 3.0 license, in subject Biochemistry, Genetics and Molecular Biology
DOI: 10.5772/791
The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication. As several contributions in this book show, the study of DNA will continue for a while to be a leading front of scientific activities.
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Book contents
- Chapter 1DNA Structure: Alphabet Soup for the Cellular Soul
- Chapter 2Replication Demands an Amendment of the Double Helix
- Chapter 3Phosphorothioation: An Unusual Post-Replicative Modification on the DNA Backbone
- Chapter 4Mitosis and DNA Replication and Life Origination Hydrate Hypotheses: Common Physical and Chemical Grounds
- Chapter 5Strand-specific Composition Bias in Bacterial Genomes
- Chapter 6Mutation Patterns Due to Converging Mitochondrial Replication and Transcription Increase Lifespan, and Cause Growth Rate-Longevity Tradeoffs
- Chapter 7Mitochondrial DNA Replication in Health and Disease
- Chapter 8Damage and Replication Stress Responses
- Chapter 9Relationship between Fork Progression and Initiation of Chromosome Replication in E. coli
- Chapter 10Replication Origin Selection and Pre-Replication Complex Assembly
- Chapter 11The Coordination between DNA Replication Initiation and Other Cell Cycle Events
- Chapter 12The Organisation of Replisomes
- Chapter 13Eukaryotic Replication Barriers: How, Why and Where Forks Stall
- Chapter 14Control of Telomeric DNA Replication: Genetics, Molecular Biology, and Physiology
- Chapter 15Telomere Maintenance in Organisms without Telomerase
- Chapter 16Eukaryote DNA Replication and Recombination: an Intimate Association
- Chapter 17Cell Cycle Regulation of DNA Replication in S. cerevisiae
- Chapter 18Free Histones and the Cell Cycle
- Chapter 19Involvement of Linker Histones in the Regulation of Replication Timing
- Chapter 20Replication Timing: Evolution, Nuclear Organization and Relevance for Human Disease
- Chapter 21The Silencing Face of DNA Replication: Gene Repression Mediated by DNA Replication Factors
- Chapter 22Faithful DNA Replication Requires Regulation of CDK Activity by Checkpoint Kinases
- Chapter 23Regulation of the G1/S Transition in Adult Liver: Expression and Activation of the Cyclin Dependent Kinase Cdk1 in Differentiated Hepatocytes is Controlled by Extracellular Signals and is Crucial for Commitment to DNA Replication
- Chapter 24Binding of Human MCM-BP with MCM2-7 Proteins
- Chapter 25DNA Replication in Animal Systems Lacking Thioredoxin Reductase I
- Chapter 26Prevalence of Reactivation of Hepatitis B Virus DNA Replication in Rheumatoid Arthritis Patients
- Chapter 27Oncogenic Aspects of HPV Infections of the Female Genital Tract
- Chapter 28The Role of E2 Proteins in Papillomavirus DNA Replication
- Chapter 29Topoisomerase I and II Expression in Recurrent Colorectal Cancer Cells: A Dubious Matter
- Chapter 30Bacterial Genetics of Large Mammalian DNA Viruses: Bacterial Artificial Chromosomes as a Prerequisite for Efficiently Studying Viral DNA Replication and Functions
