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This book is indexed in
Neuroscience
Advanced Understanding of Neurodegenerative Diseases
Edited by Raymond Chuen-Chung Chang, ISBN 978-953-307-529-7, Hard cover, 442 pages, Publisher: InTech, Chapters published December 16, 2011 under CC BY 3.0 license
DOI: 10.5772/2451
Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
- Chapter 1
Alzheimer's Disease: Definition, Molecular and Genetic Factors - Chapter 2
Evidence for an Infectious Etiology in Alzheimer’s Disease - Chapter 3
Amyloid Hypothesis and Alzheimer's Disease - Chapter 4
Structure-Toxicity Relationships of Amyloid Peptide Oligomers - Chapter 5
Disruption of Calcium Homeostasis in Alzheimer’s Disease: Role of Channel Formation by β Amyloid Protein - Chapter 6
Recent Developments in Molecular Changes Leading to Alzheimer’s Disease and Novel Therapeutic Approaches - Chapter 7
Clinical Profile of Alzheimer’s Disease Non-Responder Patient - Chapter 8
Construction of Drug Screening Cell Model and Application to New Compounds Interfering Production and Accumulation of Beta-Amyloid by Inhibiting Gamma-Secretase - Chapter 9
Therapeutics of Alzheimer’s Disease - Chapter 10
Frontotemporal Lobar Degeneration - Chapter 11
From Protein Tangles to Genetic Variants: The Central Role of Tau in Neurodegenerative Disease - Chapter 12
Gut Hormones Restrict Neurodegeneration in Parkinson’s Disease - Chapter 13
Grape Secondary Metabolites – Benefits for Human Health - Chapter 14
Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins - Chapter 15
The Effects of Trimethylamine N-Oxide on the Structural Stability of Prion Protein - Chapter 16
Modeling Spinal Muscular Atrophy in Mouse: A Disease of Splicing, Stability, and Timing - Chapter 17
Wallerian Degeneration in Injury and Diseases: Concepts and Prevention - Chapter 18
Mesenchymal Stem Cell Therapy for Apoptosis After Spinal Cord Injury - Chapter 19
Modelling Multiple Sclerosis In Vitro and the Influence of Activated Macrophages - Chapter 20
Amyotrophic Lateral Sclerosis
